Research Lab Manager

Seattle, Washington, Overview Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington. With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality. At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion. The Ring Lab of Synthetic and Systems Immunopharmacology is located within the Translational Science and Therapeutics Division and is a member of the Immunotherapy Integrated Research Center (IIRC). Their primary focus is on developing unique and first-in-class therapeutic drugs for cancer immunotherapy using cutting-edge protein engineering with directed evolution. The lab has developed therapeutics that are currently in clinical trials, such as ST-067 (a “decoy-resistant” IL-18), MDNA-11 (CD122-biased IL-2), and ALX-148/evorpacept (an ultra-high affinity SIRPa decoy). Moreover, the Ring Lab is actively working on developing platforms for discovering new targets in cancer immunotherapy, such as the REAP platform for discovering autoantibodies in patient samples, and high-throughput approaches in synthetic antibody discovery and characterization to identify new tumor antigens. The Ring Lab is seeking a highly motivated individual to support their preclinical and translational research. The successful candidate will have the opportunity to work on cutting-edge techniques to study immune responses in preclinical models and human cancer patients and to develop new therapeutic agents to advance into clinical trials. Responsibilities This is a long-term position that requires overseeing the day-to-day operations of the laboratory in conjunction with senior laboratory members. The Research Lab Manager provides leadership to an entire laboratory or program and collaborates with Principal Investigator(s) (PI) to develop goals and objectives that align with overall organizational strategy.

Responsibilities also include development of policies, procedures and methods; oversight of laboratory staff; management of projects and resources; and act as liaison and point of contact for laboratory. The successful applicant will also be responsible for contributing to various drug discovery and target identification projects. In addition to the above duties, the successful applicant will work with the PI and laboratory members to: Manage the laboratory, including procurement of supplies, oversight of laboratory equipment, and regulatory compliance for EHS, Human Subjects, and IACUC protocols. Oversee laboratory operations, providing leadership and guidance, support collaboration, facilitate projects, and identify infrastructure and technological needs. Provide technical assistance for ongoing studies, including protein engineering/synthetic antibody discovery, autoantibody screening of patient samples, and preclinical tumor modeling. Design and perform complex lab experiments and manage laboratory/program projects and resources; work with internal and external partners to define project goals, resources, priorities; allocate and monitor effort and progress, redistribute or negotiate addition of resources as required; and ensure deliverables are completed within projected timelines. Train and supervise junior laboratory members on various techniques and procedures. Develop and implement laboratory/program policies, procedures, systems, standard operating procedures (SOPs), and study specific protocols within broader framework of program/division. Participate in preparation of grant applications, manuscripts, and scientific presentations. Oversees special projects and new initiatives of the PI as requested.

Qualifications Required Bachelor’s degree in related field, graduate degree preferred Three to five years’ progressive experience in a research laboratory setting or related Two to three years of laboratory management experience Experience in immunology, protein engineering, and/or advanced molecular biology Preferred Experience with yeast/phage display, next-generation sequencing, preclinical mouse tumor models, and flow cytometry Willingness and ability to develop expertise in new research areas Fred Hutchinson Cancer Center has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations. As a condition of employment, newly hired employees must, prior to their first day of employment: Provide proof of being fully vaccinated against COVID-19 ; ORInitiate the accommodations process to request a religious or medical accommodation (medical accommodations require a healthcare provider’s certification). A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists. The annual base salary range for this position is from $86,078 to $129,118 and pay offered will be based on experience and qualifications. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (12-22 days per year), paid sick leave (12-25 days per year), paid holidays (13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 6 months). Our Commitment to Diversity We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer.

We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch. org or by calling 206-667-4700.

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